Table 3.
Comparison of demographic and clinical profile of those without (Group I) and with (Group II) current psychiatric illness
| Variable | Mean (SD)/Group I (n=128), n (%) | Mean (SD)/Group II (n=111), n (%) | T/χ2 (P) |
|---|---|---|---|
| Age of onset of Parkinson’s disease | 57.1 (7.8) | 52.7 (8.0) | −4.3 (<0.001)*** |
| Duration of Parkinson’s disease (months) | 47.4 (51.7) | 77.2 (44.2) | 4.8 (<0.001)*** |
| Both Syndopa plus and Syndopa | 62 (48.4) | 32 (28.8) | 9.6 (0.002)** |
| Syndopa | 83 (64.8) | 58 (52.3) | 3.9 (0.048)* |
| UPDRS | |||
| UPDRS - mentation, behavior, and mood | 5.9 (2.1) | 9.4 (1.9) | −13.7 (<0.001)*** |
| UPDRS - activities of daily living | 18.5 (5.6) | 29.8 (5.4) | −15.8 (<0.001)*** |
| UPDRS - motor examination | 20.3 (5.3) | 32.2 (5.5) | −17.0 (<0.001)*** |
| Total score in UPDRS (I+II+III) | 44.6 (10.9) | 71.4 (11.2) | −18.6 (<0.001)*** |
| UPDRS - complications of therapy (past week) | |||
| Dyskinesia (%) days | |||
| <50 | 115 (89.8) | 59 (53.2) | 40.4 (<0.001)*** |
| >50 | 13 (10.2) | 52 (46.8) | |
| Disability due to dyskinesia | |||
| No to moderate | 108 (84.4) | 65 (58.6) | 19.8 (<0.001)*** |
| Severe to complete | 20 (15.6) | 46 (41.4) | |
| Painful dyskinesia | |||
| No to moderate | 102 (79.7) | 65 (58.6) | 12.6 (<0.001)*** |
| Severe to marked | 26 (20.3) | 46 (41.4) | |
| Early morning dystonia# - Yes | 0 | 95 (85.6) | 17.5 (<0.0010*** |
| UPDRS - Clinical fluctuations | 85 (66.4) | 46 (41.4) | 15.0 (<0.001)*** |
| Are “off” periods predictable? - Yes | |||
| UPDRS - clinical fluctuations | |||
| For what proportion of the waking day is the patient “off” on average? (%) days | |||
| <50 | 87 (68.0) | 96 (86.5) | 11.4 (0.001)** |
| 51-75 | 41 (32.0) | 15 (13.5) | |
| Other complications: GI symptoms - Yes | 40 (31.3) | 83 (74.8) | 45.1 (<0.001)*** |
| Other complications: Sleep disturbances - Yes | 128 (100) | 111 (100) | 1.00 |
| Other complications: Symptomatic orthostasis - Yes | 52 (40.6) | 90 (81.1) | 40.4 (<0.001)*** |
| UPDRS - modified Hoehn and Yahr staging | |||
| <Stage 2.5 | 127 (99.2) | 58 (52.3) | 72.3 (<0.001)*** |
| >Stage 2.5 | 1 (0.8) | 53 (47.7) | |
| UPDRS - Schwab and England Activities of Daily Living (percentage) | 55.9 (8.2) | 47.9 (4.7) | 9.0 (<0.001)*** |
| Physical comorbidity | |||
| Diabetes mellitus | 10 (7.8) | 19 (17.1) | 4.8 (0.028)* |
*P<0.05;**P<0.01; ***P<0.001; #Yates correction. UPDRS – United Parkinson’s Disease Rating Scale; GI – Gastrointestinal