Table 4.
Comparison of demographic and clinical profile of those without (Group I) and with (Group II) lifetime psychiatric illness
| Variable | Mean (SD)/Group I (n=112), n (%) | Mean (SD)/Group II (n=127), n (%) | T/χ2 (P) |
|---|---|---|---|
| Age of onset of Parkinson’s disease | 57.3 (7.9) | 51.8 (7.6) | −5.5 (<0.001)*** |
| Duration of Parkinson’s disease (months) | 43.9 (49.4) | 85.3 (40.9) | 7.0 (<0.001)*** |
| Both Syndopa plus and Syndopa | 59 (52.7) | 35 (27.6) | 15.7 (<0.001)*** |
| UPDRS | |||
| UPDRS - mentation, behavior, and mood | 5.6 (2.0) | 9.2 (2.0) | −14.0 (<0.001)*** |
| UPDRS - activities of daily living | 17.5 (4.7) | 29.2 (5.7) | −17.2 (<0.001)*** |
| UPDRS – motor examination | 19.2 (4.4) | 31.7 (5.6) | −19.1 (<0.001)*** |
| Total score in UPDRS (I+II+III) | 42.3 (8.6) | 70.1 (11.7) | −20.7 (<0.001)*** |
| UPDRS - complications of therapy (past week) | |||
| Dyskinesia (%) days | |||
| <50 | 104 (92.9) | 70 (55.1) | 42.8 (<0.001)*** |
| >50 | 8 (7.1) | 57 (44.9) | |
| Disability due to dyskinesia | |||
| No to moderate | 97 (86.6) | 76 (59.8) | 21.3 (<0.001)*** |
| Severe to complete | 15 (13.4) | 51 (40.2) | |
| Painful dyskinesia | |||
| No to moderate | 92 (82.1) | 75 (59.1) | 15.1 (<0.001)*** |
| S-evere to marked | 20 (17.9) | 52 (40.9) | |
| Early morning dystonia#-Yes | 0 | 16 (12.6) | 13.2 (<0.001)*** |
| UPDRS - clinical fluctuations | 77 (68.8) | 54 (42.5) | 16.5 (<0.001)*** |
| Are “off” periods predictable? - Yes | |||
| UPDRS - clinical fluctuations | 71 (63.4) | 60 (47.2) | 6.3 (0.012)* |
| Do “off” periods come on suddenly within a few seconds? - Yes | |||
| UPDRS - clinical fluctuations | |||
| For what proportion of the waking day is the patient “off” on average? (%) days | |||
| <50 | 79 (70.5) | 104 (81.9) | 4.3 (0.039)* |
| 51-75 | 33 (29.5) | 23 (18.1) | |
| Other complications: GI symptoms - Yes No | 39 (34.8) | 84 (66.1) | 23.4 (<0.001)*** |
| Other complications: Sleep disturbances - Yes | 112 (100) | 127 (100) | 5.2 (0.023)* |
| Other complications: Symptomatic orthostasis - Yes | 52 (46.4) | 90 (70.9) | 14.7 (<0.001)*** |
| UPDRS - modified Hoehn and Yahr staging# | |||
| <Stage 2.5 | 112 (100) | 73 (57.5) | 59.1 (<0.001)*** |
| >Stage 2.5 | 0 | 54 (42.5) | |
| UPDRS - Schwab and England Activities of Daily Living (percentage) | 56.5 (8.4) | 48.4 (4.8) | 9.4 (<0.001)*** |
| Physical comorbidity | |||
| Diabetes mellitus | 8 (7.1) | 21 (16.5) | 4.9 (0.026)* |
*P<0.05; ***P<0.001; #Yates correction. UPDRS – United Parkinson’s Disease Rating Scale; GI – Gastrointestinal; SD – Standard deviation