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. 2021 Jun 7;1(7):998–1013. doi: 10.1021/jacsau.1c00160

Figure 1.

Figure 1

Mechanistic study of the pH-dependent degradation and NO-release reactivity of DNIC-1. Time-dependent change of UV–vis spectra for DNIC-1 (a) at pH = 7.4 and (b) in SIF (pH 6.8). (c) Decompositions of DNIC-1 at pH = 7.4 (blue), in SIF (magenta), and in SGFsp (black), which were fitted to pseudo-first-order kinetics. Data show the mean ± SD from three independent experiments. (d) Half-life for the pH-dependent decomposition of DNIC-1 at 37 °C. Data represent the mean ± SD (n = 3). (e) Equivalent of released nitric oxide during the degradation of DNIC-1. The data are the mean values ± SD pooled from three independent experiments. (f) S and (g) Fe K-edge XAS for the degradation byproducts obtained from the decomposition of DNIC-1 in SIF (black) and in SGFsp (red). S K-edge XAS of (SCH2CH2COOH)2 is shown in blue. (h) Time-dependent change of UV–vis spectra for DNIC-1 in SGFsp (pH 1.2). (i) GC chromatograms for the gaseous byproduct, N2O(g), derived from the decomposition of DNIC-1 in SGFsp (black), in SIF (magenta), and at pH = 7.4 (blue). (j) Cl K-edge XAS for the degradation byproducts obtained from the decomposition of DNIC-1 in SIF (black) and in SGFsp (red). Cl K-edge XAS of FeCl3 is shown in blue.