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. 2021 Aug 16;22(16):8769. doi: 10.3390/ijms22168769

Figure 2.

Figure 2

Cell-free in vitro and in silico models of Aβ peptides and tau proteins. (A) Fibrillization models of Aβ peptides and tau proteins based on ThT assays. (B) Structural models of Aβ1–42 peptides and 441-residue tau protein by Gremer et al. (2017) [57] and Popov et al. (2019) [58], respectively. (C) Models of protein diffusion of Aβ peptides and tau proteins in the brain developed by Weickenmeier et al. (2018) [59] and Yang et al. (2019) [60]. Abbreviations. ThT: Thioflavin T; MDS: molecular dynamic simulations.