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. 2021 Aug 2;7(3):47. doi: 10.3390/ncrna7030047

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Examples of genomic variants affecting non-coding RNAs function. (A) 3′UTR-occurring SNPs disturb miRNA targeting via sequence-based mismatches. (B) SNPs in pri-miRNA transcript can alter miRNA biogenesis. (C) SNPs can affect lncRNA–protein interactions via alterations in lncRNA secondary structure (D) SNPs can alter lncRNA stability via modulation of miRNA binding sites. UTR—Untranslated region, pri-miRNA—primary miRNA, pre-miRNA—precursor-miRNA, lncRNA—long non-coding RNA, miRNA—microRNA, GLS—glutaminase, GAC—glutaminase isoform C, KGA— kidney glutaminase isoform. Created with BioRender.com, permission: 15 July 2021.