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. 2021 Aug 14;22(16):8737. doi: 10.3390/ijms22168737

Figure 7.

Figure 7

Close-up views of the capping at the top (a) and lower (b) ends of the TP3-T6 target, rendered with the software ChimeraX [15]. (a) The G2 and G14 bases at the 5′-end, interacting via reverse Hoogsteen bonding, prevent the ligands interacting with the 5′-end tetrad (G3-G12-G15-G21). (b) C7 and C8 bases, allowing the ligands a partial but effective π–π stacking interaction to the G17 and G23 bases at the 3′-end. Nucleotide bases are represented as slabs and filled sugars. Guanine residues are colored green, thymine residues are colored in blue, and cytosine residues are colored in yellow.