Table 1.

Thermodynamic parameters associated with the folding of the G-quadruplex structure in the absence and presence of several ligands. A two-state process was assumed.

System	Tm (°C)	ΔH (kcal·mol−1)	ΔS (cal·K−1·mol−1)	ΔG37 °C (kcal·mol−1)
TP3T6	59.6 ± 0.8	−39.0 ± 0.4	−117.2 ± 1.0	−2.7 ± 1.1
TP3T6:LOM1392	60.2 ± 1.0	−43.1 ± 0.5	−129.2 ± 1.5	−3.0 ± 1.6
TP3T6:ABT888	58.8 ± 1.3	−41.1 ± 0.6	−123.7 ± 1.9	−2.7 ± 2.0
TP3T6:MK4827	60.3 ± 1.3	−41.1 ± 0.6	−123.0 ± 1.8	−3.0 ± 1.9