Table 3.

Regulation of ASC by E3 ligase and deubiquitinase.

Name	Regulation of Inflammasome Activation	Impact on ASC	Type of UB Linkage	Ubiquitination Site	Stage of NLRP3 Activation	Reference
LUBAC	Positive	Linear ubiquitination	M1	PYD	Priming	[119]
TRAF3	Positive	Ubiquitination at K174	K63	K174	Priming	[122]
TRAF6	Negative	Ubiquitination	K63	Not identified	Not identified	[123]
USP50	Positive	Deubiquitination	Not identified	Not identified	Activation	[124]