Figure 5.
In vitro uptake of MRI contrast agents in HT1080. (A) OATP-expressing and untransduced HT1080 cells were treated with MRI contrast agents. The inhibitor group was incubated at 4 °C. After PBS washing three times, cells were scanned with a 1.5-T MRI system. (B) The quantitative signal intensity of cell MRI (n = 3). Error bars show the SEM, and ** and **** represent p < 0.01 and p < 0.0001, respectively. C, control; 1B1, OATP1B1-expressing cells; (−), inhibitor group; (+), normal group; P, Primovist; M, MultiHance.