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Effects of regular exercise on cortical Aβ load in the 5xFAD mouse model. (A) Representative images of Aβ staining in cortical layer V of 5xFAD-SED and 5xFAD-EXE mice. Scale bar 200 μm. (B) Percentage of immunoreactive area was quantified to measure Aβ content in cortical layer V. All data are relative to 5xFAD-SED and presented as mean ± SEM. n = 8/group. «#» exercise effect: # p < 0.05.
