Table 2.
Condition of tissues from the proximal tibia condyle near the dental implants after surgery using MSC EVs (S ± σ).
| Parameter | Time after Implantation | ||
|---|---|---|---|
| 3 Days | 7 Days | 10 Days | |
| Total bone density near the implant (optical units) |
1974 ± 248 * | 1732 ± 204 | 1948 ± 283 |
| Length of bone contact with implant (LL) | - | 15.6 ± 11.3 | 75.6 ± 9.82 #,$ |
| Blood vessels (AA) | 6.08 ± 1.08 * | 11.9 ± 2.2 # | 11.8 ± 1.99 # |
| Numerical density of all cells (NA) | 124 ± 11.6 * | 118 ± 9.71 * | 72.2 ± 13.9 #,$ |
| Lymphocytes (%) (NA) |
12.9 ± 1.24 * 16 ± 2.03 * |
14.2 ± 1.48 16.7 ± 2.09 |
13.6 ± 1.42 9.68 ± 1.51 #,$ |
| Neutrophils (%) (NA) |
17.9 ± 1.62 22.3 ± 2.98 * |
9.22 ± 1.2 # 10.8 ± 1.35 #,* |
6.67 ± 1 # 4.74 ± 0.795 #,$ |
| Macrophages (%) (NA) |
7.5 ± 0.798 9.34 ± 1.56 |
18.2 ± 1.09 # 21.4 ± 1.67 # |
18.8 ± 1.64 #,* 13.6 ± 3 $ |
Note: LL—the relative length of structure in section (% from length of section); AA—relative area of structure in section (% from section area); NA—the numerical density of cells per 105 μm2 of the section area; #—values significantly differing from the corresponding on the 3rd day after the surgery (p ≤ 0.05); $—values significantly differing from the corresponding on the 7th day after the surgery (p ≤ 0.05); *—values significantly different from the corresponding ones after implantation without MSC EVs (p ≤ 0.05).