Table 4.

Sensitivity analysis of pH and demineralization time using meta-regressions.

Univariate				Multivariate
Charateristics	B	95% CI	p-Value	B	95% CI	p-Value
Surface roughness of WSLs
pH	−0.51	−2.96; 1.93	0.6806	−1.37	−2.32; −0.42	0.00451
Demineralization time (hours)	0.00	−0.00; 0.01	1.8929	0.01	0.00; 0.01	<0.0001
Enamel microhardness of WSLs
pH	0.42	−3.42; 0.67	0.0641	0.42	−0.03; 0.00	0.0647
Demineralization time (hours)	0.00	−0.01; 0.00	0.6230	0.00	−0.01; 0.00	0.8729
Shear Bond Strength of WSLs
pH	−0.59	−6.98; 7.62	0.9781	−0.60	−2.02; 0.82	0.4098
Demineralization time (hours)	0.00	0.00; 0.01	0.0015	0.00	0.00; 0.01	0.0120
Penetration depth of WSLs
pH	−6.24	−54.77; 42.29	0.8010	−33.63	−0.88; 290.10	0.0432
Demineralization time (hours)	0.00	−0.02; 0.02	0.9969	0.00	−0.01; 0.01	0.8542
Time of application of resin infiltrate (minutes)	7.68	1.17; 14.18	0.0207	24.12	13.16; 35.07	<0.0001

CI—Confidence Interval.