Figure 5.

Melanoma ex-giant congenital nevus, 8-year-old (hematoxylin, phloxin, safranin stain). (A): Low-magnification silhouette: loose horizontal band of melanocytes under a verrucous epidermis elevated by a large cellular dermal nodule with hyperpigmented areas and patch of tumoral necrosis. (B): Close-up view on transition area with the congenital nevus made of loose bland melanocytes in the upper dermis separated by fibrous collagen from the dense nests of the melanoma underneath. (C,D): High-power view of the melanoma with confluent nests of large epithelioid and nevoid melanocytes; mitotic figure (arrow).