Table 1.
Examples of functional lncRNA-derived micropeptides.
| Micropeptide | Species | Target | Function(s) | Ref. |
|---|---|---|---|---|
| NoBoDy | Human | mRNA decapping factors | Regulation of mRNA turnover and P-body numbers | [160] |
| CASIMO1 | Human | Squalene epoxidase | Carcinogenesis; cell lipid homeostasis | [171] |
| PINT87aa | Human | Polymerase associated factor complex (PAF1c) | Oncogene transcriptional inhibition; tumor suppressive effect | [154] |
| HOXB-AS3 | Human | hnRNP A1 splicing factor | Colon cancer growth suppression | [173] |
| RBRP | Human | m6A reader IGF2BP1 | Regulation of m6A recognition by IGF2BP1 on c-Myc mRNA; tumorigenesis | [172] |
| Minion/ Myomixer |
Human, mouse | Unknown | Myoblast fusion; muscle formation and development | [163,164,167] |
| SPAR | Human, mouse | Lysosomal v-ATPase | Regulation of mTORC1 signaling pathway; muscle regeneration | [166] |
| TUG1-BOAT | Human, mouse | Unknown | Unknown; alters mitochondrial membrane potential when overexpressed | [174] |
| Mtln | Human, mouse | Cardiolipin | Increase of mitochondrial functions | [175] |
| DWORF | Mouse | SERCA | SERCA (sarcoplasmic reticulum Ca2+-ATPase) activation | [168,169] |
| MLN | Mouse | SERCA | SERCA inhibition | [176] |
| Toddler | Zebrafish | Unknown | Promoting cell migration during embryogenesis | [174] |
| Pri | Drosophila | Ubr3 E3 ubiquitin ligase | Proteasome-dependent processing of the developmental Svb transcription factor | [162] |
| Scl | Drosophila | Ca-P60A SERCA | Calcium transport regulation | [170] |