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Protein knockdown by small molecule-based and peptide-based PROTACs and SNIPERs (a) The mechanism of protein knockdown by PROTACs and SNIPERs. (b) Schematic showing targeted protein (ERα) degradation using SNIPER based on PERML-R7. Abbreviation: ERα; estrogen receptor α, Ub; ubiquitin, IAP; inhibitor of apoptosis protein, VHL; von Hippel-Lindau, CRBN; cereblon.
