95% CI	95% confidence interval
Ach	acetylcholine
AMPK	AMP-activated protein kinase
Apaf-1	apoptosis protease-activating factor 1
ATF-3	activating transcription factor 3
Bcl-2	B-cell lymphoma 2
Bcl-xL	B-cell lymphoma-extra large
BDNF	brain derived neurotrophic factor
CaMKIIα	calmodulin-dependent protein kinase IIα
CCL2	C-C motif chemokine ligand 2
CCR2	C-C motif chemokine receptor 2
CGRP	calcitonin gene-related peptide
CPNE	composite peripheral nerve electrophysiology
CREB	cAMP response element binding protein
CXCL	C-X-C motif chemokine ligand
CXCR	C-X-C motif chemokine receptor
CYP2J	Cytochrome P450 2J
DRG	dorsal root ganglia
EAAT2	excitatory amino acid transporter 2
EORTC QLQ-CIPN20	European Organisation for Research and Treatment of Cancer: Quality of Life-Chemotherapy-Induced Peripheral Neuropathy 20
EPA	eicosapentaenoic acid
Epac	exchange protein directly activated by cAMP
EpOME	epoxyoctadecamonoenoic acids
ER	endoplasmic reticulum
ERK	extracellular signal-regulated kinase
FAAH	fatty-acid amide hydrolase
FosB	FBJ murine osteosarcoma viral oncogene homolog B
GAT-1	gamma-aminobutyric acid (GABA) transporter 1
GFAP	glial fibrillary acidic protein
GluR1	glutamate ionotropic receptor AMPA type subunit 1
GSH	glutathione
HDAC2	histone deacetylase 2
HMGB1	high mobility group box 1
HO-1	heme oxygenase 1
i.p.	intraperitoneal
i.v.	intravenous
IENF	intra-epidermal nerve fibres
IL-10	interleukin-10
IL-1β	interleukin-1 beta
IL-6	interleukin-6
IL-8	interleukin-8
iNOS	inducible nitric oxide synthase
IRF8	interferon regulatory factor 8
JNK	c-Jun N-terminal kinase
LIF	leukaemia inhibitory factor
MAGL	monoacylglycerol lipase
MAPK	mitogen-activated protein kinase
MCP-1	monocyte chemotactic protein 1
MDA	malondialdehyde
MEK	mitogen-activated protein kinase kinases
MPO	myeloperoxidase
mTNS	modified total neuropathy score
mTOR	mammalian target of rapamycin
NAAA	N-acylethanolamine-hydrolyzing acid amidase
nAChR	nicotinic acetylcholine receptor
NCI-CTCAE	National Cancer Institute-Common Terminology Criteria for Adverse Events
NCV	nerve conduction velocity
NF-κB	nuclear factor kappa-B
NGF	nerve growth factor
NMDA	N-methyl-D-aspartate
NOX4	nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4
NQO1	NAD(P)H dehydrogenase [quinone] 1
NR2B	N-methyl D-aspartate (NMDA) receptor subtype 2B
Nrf2	nuclear factor-erythroid 2-related factor 2
NTX score	neurotoxicity score
OATP1B2	organic anion-transporting polypeptide 1b2
p.o.	per os
p-Akt	phospho-protein kinase B
PARP	poly ADP-ribose polymerase
p-CREB	phospho-cAMP response element binding protein
PDE	phosphodiesterase
p-FAK	phspho-fokal adhesion kinase
PGC-1α	peroxisome proliferatoractivated receptor γ coactivator-1
PI3K	phosphatidylinositol-3 kinase
PIPN	paclitaxel-induced peripheral neuropathy
p-JAK2	phospho-janus kinase 2
PKA	protein kinase A
PKC	protein kinase C
p-NF-κB	phospho-nuclear factor kappa-B
PNP score	peripheral neuropathy score
PNQ	patient neurotoxicity questionnaire
p-p38	phospho-p38
PPAR-α	peroxisome proliferator-activated receptor-α
p-STAT3	phospho-signal transducer and activator of transcription 3
QOL	quality of life
RAGE	receptor for advanced glycation endproducts
RR	relative risk
s.c.	subcutaneous
SIRT1	sirtuin-1
SNAP	sensory nerve action potential
SNCV	sensory nerve conduction velocity
SOD	superoxide dismutase
TLR4	Toll-like receptor 4
TNF-α	tumour necrosis factor-α
TRP	transient receptor potential
TRPA1	transient receptor potential ankyrin 1
TRPV1	transient receptor potential vanilloid 1
TRPV4	transient receptor potential vanilloid 4
UCP2	uncoupling protein 2
VGLUT	vesicular glutamate transporter 3
YY1	Yin-Yang 1