Extended Data Fig. 5.

Impact of pharmacologic perturbation with cisplatin on fitness landscapes in TNBC-SA1035. a) Copy number genotype of Clone E from the untreated timeseries. b) Copy number genotype of clone H from treated timeseries (arrows indicate differences to Clone E). c) Evolution in absence of treatment and as a function of drug treatment. For each sample, the phylogeny with clonal abundance from DLP+ is shown, reflecting selection. d) The observed clonal abundances and e) the summarised clonal phylogenetic tree.