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. 2021 Aug 18;22(16):8907. doi: 10.3390/ijms22168907

Figure 9.

Figure 9

Influence of different monoaminergic receptors’ antagonists on o-PIT’s anticompulsive effects in TAAR1-KO and WT mice. (A) Schematic depiction of the possible monoaminergic receptors that may bind o-PIT. (B–F) Values correspond to the number of hidden marbles over 30 min after pretreatment of raclopride (10 mg/kg) (B), RX821002 (0.65 mg/kg) (C), WAY100635 (0.63 mg/kg) (D), MDL100907 (0.16 mg/kg) (E) or SB206553 (2.5 mg/kg) (F) and acute o-PIT treatment (20 mg/kg). Data represent means ± SEM. N = 8–12 per group. p < 0.05, vehicle + vehicle vs. vehicle/antagonist + o-PIT (#), antagonist + vehicle vs. antagonist + o-PIT (§). VEH: vehicle.