Table 1.

Resting levels and o-PIT-induced changes in biogenic amines, acetylcholine and amino acids in dialysates of mPFC in freely moving mice. Values are mean ± SEM concentration not corrected for probe recovery. N ≥ 8 per groups. * p < 0.05 WT vs. TAAR1-KO.

		Resting Levels		o-PIT (10 mg/kg i.p.) [AUC; % of Vehicle]
	(Units)	WT	TAAR1-KO	WT	TAAR1-KO
DA	(pM)	238.87 ± 30.13	203.49 ± 23.84	160 ± 13	109 ± 6 *
NA	(pM)	445.49 ± 25.79	411.87 ± 22.47	115 ± 5	106 ± 4
5-HT	(pM)	188.29 ± 15.19	209.08 ± 22.40	109 ± 8	102 ± 4
Acetylcholine	(nM)	0.92 ± 0.10	1.13 ± 0.14	98 ± 7	107 ± 20
Alanine	(µM)	0.90 ± 0.12	1.18 ± 0.21	94 ± 3	84 ± 4
Arginine	(µM)	0.38 ± 0.07	0.48 ± 0.10	89 ± 2	91 ± 4
Aspartate	(µM)	70.83 ± 20.45	69.98 ± 20.50	103 ± 5	105 ± 6
GABA	(µM)	10.74 ± 1.82	13.24 ± 3.19	87 ± 8	82 ± 8
Glutamate	(µM)	2.05 ± 0.71	1.64 ± 0.83	106 ± 3	101 ± 3
Glutamine	(µM)	9.55 ± 2.26	13.61 ± 3.73	106 ± 5	101 ± 5
Glycine	(µM)	1.08 ± 0.10	1.53 ± 0.29	93 ± 2	90 ± 2
Phenethylamine	(µM)	0.40 ± 0.08	0.32 ± 0.09	108 ± 3	114 ± 6
L-serine	(µM)	1.31 ± 0.18	1.58 ± 0.25	96 ± 2	96 ± 5
D-serine	(µM)	0.45 ± 0.09	0.35 ± 0.06	95 ± 4	107 ± 4
Taurine	(µM)	6.92 ± 1.64	6.99 ± 3.20	116 ± 6	105 ± 4