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. 2021 Aug 17;22(16):8841. doi: 10.3390/ijms22168841

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of SCU on EMT markers and migration-related proteins in HepG2 cells. (a) SCU induces EMT-related proteins E-cadherin and suppresses N-cadherin and Snail levels in HepG2 cells. Cells were treated with SCU (0, 25, 50, and 100 μM) for 48 h. (b) SCU induces extracellular inhibitor of MMPs: TIMP2 and suppresses migration-related proteins MMP-2 and MMP-9 levels in HepG2 cells. The results obtained from three independent experiments were expressed as mean ± standard deviation (SD) compared with the control group. * p < 0.05, ** p < 0.01, *** p < 0.001.