Figure 1.

Principle modes of action of mAb. The combination of the antigen-specificity and different Fc-mediated effects result in different MoA of mAbs. Depleting mAbs induce the elimination of the target cell via FcγR-mediated ADCC or ADCP. Agonists bind with higher affinity to a respective receptor than its ligand without eliciting FcγR-mediated effects. Blocking antibodies bind ligands or receptors without engaging FcγR activation and thereby inhibit the respective downstream events. Furthermore, mAbs can be designed to specifically block receptors and induce depletion of target cells at the same time.