Figure 4.

Possible mAb Fc-related modifications. The large variety of mAb-modifications concerning the Fc part can be grouped into four main categories, as illustrated with simplified representatives. The Fc-mediated effector functions can be influenced by changing the glycosylation-pattern of the mAb (glyco-engineering) or by introducing (point) mutations in the Fc domain. Furthermore, exchanges of distinct Fc domains with the respective domains derived from another IgG subclass are applicable to modify effector functions. The last category comprises the truncation of the Fc domain, which results in mAbs incapable of eliciting FcγR-mediated downstream events.