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. 2021 Aug 17;22(16):8848. doi: 10.3390/ijms22168848

Figure 2.

Figure 2

PFKFB4 gene structure and alternative splicing isoforms. (A) Schematic representation of the exon-intron organization of the PFKFB4 gene. (B) Alternative splicing of PFKFB4 pre-mRNA. Constitutive exons, present in all final mRNAs are shown in white. Alternative cassette exons that may be included or excluded are shown in black. Alternative promoters are patterned. (C) Comparison of six PFKFB4 isoforms resulting from alternative splicing. The mRNA sequences were obtained from the NCBI Gene database with the following codes: isoform A (NM_001317134.2), isoform B (NM_004567.4), isoform C (NM_001317135.2), isoform D (NM_001317136.2), isoform E (NM_001317137.2), and isoform F (NM_001317138.2).