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. 2021 Aug 17;22(16):8848. doi: 10.3390/ijms22168848

Figure 5.

Figure 5

Visualization of PFKFB4 protein and its catalytic domains. (A) Left upper panel: Key amino acids of 6-PF-2-K and Fru-2,6-P2ase active sites. Right upper panel: Structure of Rattus Norvegicus PFKFB4 protein. The structure was obtained from the Protein Data Bank database with the following code: 1BIF. The protein was visualized using VMD software. The visualized sequence starts from the 38th amino acid (cysteine). The alternative start of the isoforms A and D are not considered in the structure. Lower panel: Binding pockets of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Amino acids of the 6-PF-2-K active site were colored in blue and amino acids of the Fru-2,6-P2ase active site were colored in green. Based on the Hasemann et al. (B) Graphical representation of PFKFB4 protein isoforms. Amino acids of the 6-PF-2-K active site were colored in blue and amino acids of the Fru-2,6-P2ase active site were colored in green. Amino acids not present in the structure were colored in red. Left panel: view of the whole protein structure. Right panel: Focus on the catalytic centers.