Table 2.
Frequency distribution of psychotropic medications (N = 47; as percentage; in descending order of prescribing frequency) being prescribed to the study cohort (N = 435) at any time during the study period, and their respective pharmacogenetics information.
| Generic Name | Medication Type | Prescribing Frequency (%) | Guideline | Genotype |
|---|---|---|---|---|
| Guanfacine | ADHD Medication | 49.9 | None | None |
| Sertraline | Antidepressant | 43.0 | CPIC | CYP2C19 |
| Risperidone | Antipsychotic | 34.9 | FDA | CYP2D6 |
| Methylphenidate | ADHD Medication | 33.3 | None | None |
| Aripiprazole | Antipsychotic | 32.6 | FDA | CYP2D6 |
| Fluoxetine | Antidepressant | 29.4 | FDA | CYP2D6 |
| Mixed amphetamine salts | ADHD Medication | 25.3 | None | None |
| Lamotrigine | Mood stabilizer | 18.9 | None | None |
| Atomoxetine | ADHD Medication | 16.3 | CPIC, FDA | CYP2D6 |
| Lisdexamfetamine | ADHD Medication | 14.9 | None | None |
| Citalopram | Antidepressant | 14.7 | CPIC, FDA | CYP2C19, CYP2D6 |
| Trazodone | Antidepressant | 14.7 | None | None |
| Quetiapine | Antipsychotic | 14.5 | None | None |
| Dexmethylphenidate | ADHD Medication | 13.3 | None | None |
| Escitalopram | Antidepressant | 12.6 | CPIC, FDA | CYP2C19, CYP2D6 |
| Valproic acid | Mood stabilizer | 9.0 | FDA | POLG |
| Olanzapine | Antipsychotic | 8.3 | None | None |
| Topiramate | Mood stabilizer | 8.3 | None | None |
| Venlafaxine | Antidepressant | 8.3 | FDA | CYP2D6 |
| Bupropion | Antidepressant | 7.6 | None | None |
| Desvenlafaxine | Antidepressant | 7.4 | FDA | CYP2D6 |
| Oxcarbazepine | Mood stabilizer | 7.4 | CPIC, FDA | HLA-B*1502 |
| Gabapentin | Mood stabilizer | 6.9 | None | None |
| Clonidine | ADHD Medication | 6.5 | None | None |
| Lithium | Mood stabilizer | 6.4 | None | None |
| Amitriptyline | Antidepressant | 5.5 | CPIC, FDA | CYP2C19, CYP2D6 |
| Lurasidone | Antipsychotic | 4.1 | None | None |
| Ziprasidone | Antipsychotic | 3.7 | None | None |
| Duloxetine | Antidepressant | 2.8 | FDA | CYP2D6 |
| Fluvoxamine | Antidepressant | 2.5 | CPIC, FDA | CYP2D6 |
| Dextroamphetamine | ADHD Medication | 2.1 | None | None |
| Mirtazapine | Antidepressant | 1.8 | None | None |
| Asenapine | Antipsychotic | 1.6 | None | None |
| Carbamazepine | Mood stabilizer | 1.2 | CPIC, FDA | HLA-B*1502, HLA-A*3101 |
| Vilazodone | Antidepressant | 0.9 | None | None |
| Clomipramine | Antidepressant | 0.7 | CPIC, FDA | CYP2D6 |
| Paliperidone | Antipsychotic | 0.7 | None | None |
| Clozapine | Antipsychotic | 0.5 | FDA | CYP2D6 |
| Imipramine | Antidepressant | 0.5 | CPIC, FDA | CYP2D6, CYP2C19 |
| Doxepin | Antidepressant | 0.2 | CPIC, FDA | CYP2C19, CYP2D6 |
| Haloperidol | Antipsychotic | 0.2 | None | None |
| Iloperidone | Antipsychotic | 0.2 | FDA | CYP2D6 |
| Levomilnacipran | Antidepressant | 0.2 | None | None |
| Paroxetine | Antidepressant | 0.2 | CPIC, FDA | CYP2D6 |
| Perphenazine | Antipsychotic | 0.2 | FDA | CYP2D6 |
| Selegiline | Antidepressant | 0.2 | None | None |
| Thiothixene | Antipsychotic | 0.2 | None | None |