Table 1.

Summary of selected, previously published norovirus aptamers, their SELEX target, and determined K_d.

Candidate	Sequence 5′-3′	Target Protein	K d
M1 [27]	TGTTTATGGGGATAAACGTATCTAATTCGTGTACTAATCA	GII.4 P-domain with GST fusion protein	n.d. *
M6-2 [27]	TGGGAAGAGGTCCGGTAAATGCAGGGTCAGCCCGGAGAG		n.d. *
SMV19 [25]	CACCAGTGTGTTGAGGTTTGAGCACACTGATAGAGTGTCA	Whole virus GII.2	191 nM **
SMV21 [25]	CCATGTTTTGTAGGTGTAATAGGTCATGTTAGGGTTTCTG		101 Nm **
Buf-2 [29]	GAAATTGGGTTCGGGTTTGGGTTGGGATTACTTAGCGATG	GII.4 P-domain with His-Tag	17 ± 7 nM
AG3 [28]	GCTAGCGAATTCCGTACGAAGGGCGAATTCCACATTGGGCTGCAGCCCGGGGGATCC	MNV	pM range ***
Beier [26]	GTCTGTAGTAGGGAGGATGGTCCGGGGCCCCGAGACGACGTTATCAGGC	GII.4 VP1 with His-Tag	n.d. *

* n.d.: not determined. ** K_d was determined using GII.2 VLPs, not the SELEX target. *** no definitive K_d was published, but K_d was determined to be in the picomolar range based on binding studies.