Representative gross morphological findings of the knee articular surface 4 and 8 weeks post-operatively. Sham operated joints showed no significant changes on either the femoral condyles or tibial plateau (A and B, respectively). Four weeks after destabilization pathology was limited to the medial compartment and consisted of and osteophyte formation (C, arrows) opaque changes, and fibrillations, (D, arrow). Both the medial and lateral compartments developed osteoarthritic lesions following 8 weeks of destabilization (E and F, arrows).