Figure 5.

Semiquantative histopathological analysis of the medial tibia following the intra-articular administration of GlcN. The arthritic changes due to MMx are not altered through saline injections; however, locally delivered GlcN at 350 μg lowers the overall Mankin score (A). The deconvoluted Mankin scores indicate that GlcN has favorable impacts on surface structure and cellularity changes (B and D, respectively). The reduction of proteoglycan loss failed to reach statistical significance (C) As quantitatively depicted in (E and F) GlcN also reduces the calcified cartilage thickness and increases the uncalcified cartilage thickness. Statistical significance is indicated as *p < 0.05 compared to sham and **p < 0.05 compared to saline.