Figure 3.

NK cell-directed therapeutic strategies in HCC. Current therapeutic approaches based on NK cell manipulation. Four different strategies are currently being explored. This includes (i) the interference of NK cell receptors to either block the inhibitory receptors or stimulate activating receptors; (ii) the adoptive transfer of autologous/allogeneic NK cells; (iii) the stimulation of NK cells by activating cytokines or (iv) the manipulation of the microenvironment by inhibiting the immunosuppressive pathways found in HCC patients.