Table 1.

Clinical effects of augmentation of SERT inhibition with different activities towards 5-HT receptors.

Clinical Intervention	Mechanism of Action	Effect	References
SSRI + pindolol	SERT inhibition + 5-HT1A agonism	Reduced latency of the antidepressant response and improved the clinical response in previously untreated MDD patients	[21]
SSRI + buspirone	SERT inhibition + 5-HT1A partial agonism	Symptom remission in patients unsuccessfully treated with SSRIs	[75]
SSRI + mirtazapine	SERT inhibition + 5-HT2A antagonism	Augmentation of the clinical response to SSRIs in treatment-resistant patients	[76]
Vilazodone	SERT inhibition + 5-HT1A partial agonism	In contrast to prototypical SSRIs, vilazodone has not been associated with treatment-emergent sexual difficulties or dysfunction	[27]
Vortioxetine	SERT, 5-HT3 and 5-HT7 receptors inhibition, 5-HT1A agonism	Potential rapid onset of action	[77]