Figure 2.

Schematic representation of (a) fabrication of the RGD10-10R/siRNA complex, (b) tumor-targeted siRNA delivery involving ligand/receptor interactions. siRNAs accumulated in the tumor tissue and then entered the tumor cells in a receptor (αvβ3)-mediated endocytosis (RME) manner in vitro. After being internalized by cells, peptide/siRNA complexes escaped from the endosomes/lysosomes. Then, siRNAs were released from the complexes and loaded by RNA-induced silencing complex (RISC). Targeted messenger RNA complementary to the guide strand (antisense strand) of siRNA was selected and cleaved by argonaute protein. Reprinted with permission from [31]. Copyright 2015 Springer Nature.