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. 2021 Aug 23;22(16):9092. doi: 10.3390/ijms22169092

Figure 6.

Figure 6

Organelle-specific targeting of polymersome NCs into the cell nucleus. (a) NLS-NCs self-assemble from amphiphilic PMOXA-PDMS-PMOXA triblock copolymers. Two model compounds are used to test for nuclear delivery: Ruthenium red (RR) that is encapsulated within the NLS-NC lumen, and Bodipy 630/650 that incorporates into its polymeric membrane. (b) The nuclear transport mechanism involves Kapα•Kapβ1 that (1) authenticates NLS-NCs for selective NPC transport, (2) binds to FG Nups, and (3) releases NLS-NCs into the nucleus upon binding RanGTP. Reprinted with permission from [213]. Copyright 2020 National Academy of Sciences.