Skip to main content
. 2021 Aug 22;22(16):9060. doi: 10.3390/ijms22169060

Figure 1.

Figure 1

Structure of the ESCRT protein complex and its function in exosome biogenesis [24]. ESCRT-0 initiates the ESCRT pathway by recognizing ubiquitinated cargo and binding to the endosomal membrane. After ESCRT-0 recruits ESCRT-I, ESCRT-I and -II interact with each other and function to invaginate endosome membrane to form initial buds and combine with ubiquitinated cargo to form a cargo-rich area. Then, ESCRT-III is assembly in the neck of the bud. After isolating and classifying ESCRT-I, ESCRT-III drives the budding of vesicles, which are decomposed by the VPS4-VTAL complex.