Table 1.

Preclinical evidence for CB₂R-mediated modulations in epilepsy.

Modulation Approaches	Seizure or Epilepsy Model	Response	References
-	PTZ induced seizures in heterozygous and homozygous CB2 knockout mice	Susceptibility	[84]
-	Handling-induced and spontaneous seizures	Susceptibility	[81]
2-Arachidonoylglycerol (2-AG)	Kainate induced seizures in CB1R and CB2R double-knockout mice	Suppressed excitatory	[12]
CB2 agonist beta caryophyllene	PTZ induced seizures in mice	Anticonvulsant activity	[85]
CB2 agonist beta caryophyllene	Induced by kainic acid (KA) seizure in mice	Decreased the seizure scores	[85]
CB2 antagonist AM630	Kainate induced seizures in CB1R knockout mice	Increased seizure susceptibility	[80]
CB2 agonist AM1241	PTZ induced seizures in rats	Increased seizure severity	[86]
CB2 agonist HU-308	DMCM and PTZ induced seizures in rats	No significant effect on seizure severity	[80]
CB2R agonist JWH133	PTZ induced seizures in mice	No significant effect on seizure severity	[84]
CB2R antagonist SR144528	PTZ induced seizures in mice	Increases seizure susceptibility	[84]
CB1/2R mixed agonist WIN 55,212-2	DMCM and PTZ induced seizures in rats	Anticonvulsant effects	[80]