Figure 6.

HIF signaling and ECM–receptor interaction pathway proteins were increased in the hypoxic/normoxic proteome. Data shown are untargeted µDIA proteomic quantification results from 2683 proteins (the 54 proteins that are listed in Table S1 but detected only in the hypoxic or normoxic conditions and are not included in this plot). ECM–receptor interaction pathway proteins are highlighted in red, the HIF signaling protein EGLN1 is highlighted in blue, and the P4HA1/P4HA2 proteins involved in altering the extracellular matrix are highlighted in green. All other proteins are shown as black-filled ovals (p-value > 0.05) and black circles with white centers (p-value < 0.05). The vertical lines denote fold-change values of −1.3 and +1.3 (without Log transformation), and the horizontal line represents a p-value = 0.05 (without Log transformation).