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. 2021 Aug 11;19(8):e3001367. doi: 10.1371/journal.pbio.3001367

Fig 12. Model representing the signalling network involved in the activation of glial response after cell death induction in eye discs.

Fig 12

(A) In the eye discs, Hh is expressed in the interommatidial and photoreceptors cells, behind the MF (purple). The expression of Dpp is located ahead of the MF (red). JNK is expressed in the glial cells and the retina (green). (B) Damage promotes a GRR consisting of increased glial migration and division. Moreover, it is stimulated the engulfment activity of glial cells for removing cellular debris and apoptotic corpses. When cell death is induced in the retinal tissue, the Hh and Dpp pathways induce glial cell proliferation and migration and activate the JNK pathway that facilitates glial migration and engulfment. The basal displacement of photoreceptors is likely due to the restructuring of the epithelium caused by apoptotic induction. Dpp, Decapentaplegic; GRR, glial regenerative response; Hh, Hedgehog; JNK, c-Jun N-terminal kinase; MF, morphogenetic furrow.