Table 1.
Clinicopathological characteristics and the univariate analysis.
| No Metastatic Disease | Metastatic Disease | Total | p-Value | |
|---|---|---|---|---|
| gender, n (%) | 1 | |||
| male | 11 (26.8%) | 11 (26.8%) | 22 (26.8%) | |
| female | 30 (73.2%) | 30 (73.2%) | 60 (73.2%) | |
| age at diagnosis (years) | ||||
| mean ± SD | 46.5 ± 13.5 | 44.5 ± 14.7 | 45.5 ± 14.0 | 0.524 |
| age group, (years) | ||||
| <55 (mean ± SD) | 39.1 ± 8.9 | 36.5± 10.3 | 37.8 ±9.6 | 0.310 |
| ≥55 (mean ± SD) | 62.3 ± 5.8 | 61.7 ± 3.9 | 62.0 ±4.9 | 0.754 |
| pN stage, n (%) | ||||
| N0 | 41 (100%) | 1 (2.4%) | 42 (51.2%) | 0.0001 |
| N1a | 0 | 29 (70.7%) | 29 (35.4%) | |
| N1b | 0 | 11 (26.8%) | 11 (13.4%) | |
| M stage, n (%) | 0.0001 | |||
| M0 | 41 (100%) | 40 (97.6%) | 81 (98.8%) | |
| M1 | 0 | 1 (2.4%) | 1 (1.2%) | |
| AJCC TNM staging, n (%) | ||||
| I | 41 (100%) | 28 (68.3%) | 69 (84.2%) | 0.0001 |
| II | 0 | 12 (29.3%) | 12 (14.6%) | |
| IVb | 0 | 1 (2.4%) | 1 (1.2%) | |
| PTMC subtype, n (%) | ||||
| Conventional | 25 (61.0%) | 27 (65.9%) | 52 (63.4%) | 0.532 |
| Follicular variant | 12 (29.3%) | 11 (26.9%) | 23 (28.1%) | |
| Oncocytic | 3 (7.3%) | 1 (2.4%) | 4 (4.9%) | |
| Diffuse sclerosing | 0 | 1 (2.4%) | 1 (1.2%) | |
| Solid/Trabecular | 0 | 1 (2.4%) | 1 (1.2%) | |
| Columnar cell | 1 (2.4%) | 0 | 1 (1.2%) | |
| lymphatic invasion, n (%) | 0.364 | |||
| presence | 5 (12.2%) | 8 (19.5%) | 13 (15.9%) | |
| absence | 36 (87.8%) | 33 (80.5%) | 69 (84.1%) | |
| vascular invasion, n (%) | 1 | |||
| presence | 3 (7.3%) | 5 (12.2%) | 8 (9.8%) | |
| absence | 38 (92.7%) | 36 (87.8%) | 74 (90.2%) | |
| perineural invasion, n (%) | 0.712 | |||
| presence | 2 (4.9%) | 3 (7.3%) | 5 (6.1%) | |
| absence | 39 (95.1%) | 38 (92.7%) | 77 (93.9%) | |
| microscopic capsular invasion, n (%) | 1 | |||
| presence | 12 (29.3%) | 12 (29.3%) | 24 (29.3%) | |
| absence | 29 (70.7%) | 29 (70.7%) | 58 (70.7%) |
n—data expressed as patients number (%); pN—pathologic lymph node stage; M—distant metastasis; AJCC TNM—American Joint Committee on Cancer Classification of Malignant Tumors; PTMC—papillary thyroid microcarcinoma. A statistically significant difference was defined as p < 0.05; bold values are statistically significant.