Figure 2.

Annual publications associated with breast cancer drugs versus breast cancer anti-metastatic drugs. Total annual publications among breast cancer-related research in the years 1986−2021 as obtained by PubMed search. The search query used to retrieve drug-associated publications was: (“drug”|“drugs”|” treatment”|“treatments”|“therapy”|“therapies”) AND (“breast”). The search query used to retrieve antimetastatic-associated publications was: (“anti-metastatic”|“antimetastatic”|“anti-metastasis”|“antimetastasis”|“anti-invasive”|“anti-invasion”|“anti-migratory”|“anti-migration”|“anti-degradation”|“antiproteolytic”|“antiproteolysis”|“anti-MMP”|“anti-matrix metalloproteinase”|“metastasis prevention”|“metastatic prevention”|“anti-invadopodia”) OR (“invasion”|“invadopodia”|“migration”|“degradation”|“proteolysis”|“proteolytic”|“MMP”|“matrix metalloproteinase”) AND (“inhibitor”|“inhibitors”|“antagonist”|“antagonists”) AND (“breast”). The ratio between the queries is represented by a dashed line.