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Light microscopy of passage 33 BmVIII-SCC cells cultured with the hydrogel matrix showing aggregate formation. (a) Measurements of small granular endothelial-like cell aggregates of “mortar stone” morphology observed on day 25 p.i. at 200×. (b) Large vacuolated cells with enhanced intracytoplasmic organization and dense granulation (red arrows), and aggregates of smaller granular cells (yellow arrow) were distributed throughout the matrix on day 30 p.i. as observed at 400×.
