Table 4.
Hormonal regulation and function of deregulated miRNAs in endometrial cancer.
| miRNA | Sex Steroid Hormone Regulation in Endometrium | Function | Endometrial Cancer |
|---|---|---|---|
| miR-10b | vascular invasion [90] | Down-regulated [90] | |
| miR-29b | Up-regulated in secretory phase [32] | vascular invasion [90] | Down-regulated [90] |
| miR-30d | Promotion of EMT [91] | Down-regulated [91] | |
| miR-34b | Down-regulated [90] | ||
| miR-101 | Down-regulated [90] | ||
| miR-106 | Promotion of EMT [91] | Up-regulated [91] | |
| miR-133 | Up-regulated by progesterone [31] | Promotion of EMT [84]; promotion of endometrial epithelial cell proliferation [31] | Down-regulated [90] |
| miR-141 | Promotion of EMT [84]; regulation of ZEB1/ZEB2 expression [86,87,88] | Up-regulated [84,90] | |
| miR-144 | Promotion of EMT [91] | Up-regulated [91] | |
| miR-152 | Up-regulated by progesterone [48] | regulation of GLUT3 expression [48] | Down-regulated [90] |
| miR-200 | Promotion of EMT [84]; regulation of ZEB1/ZEB2 expression [86,87,88] | Up-regulated [84] | |
| miR-203 | Up-regulated in secretory phase and in implantation window [32] | Promotion of EMT [84] | Up-regulated [84] |
| miR-205 | Promotion of EMT [84] | Up-regulated [84,90] | |
| miR-224 | Promotion of EMT [84] | Down-regulated [84] | |
| miR-411 | Down-regulated [90] | ||
| miR-429 | down-regulated during implantation in mouse [45] | Promotion of EMT [84] | Up-regulated [84] |