Table 3.

Estimated mean differences in health and psychological wellbeing over time (baseline vs. follow-up) and between groups (ME/CFS vs. Control).

Measures of Health and Psychological Wellbeing	Estimated Mean Difference (b) with 95% CIs	SE	p-Value	Effect Size (Cohen’s d)
Fatigue
Time	17.89 (8.83, 26.96)	4.62	<0.001	0.66
Group	41.62 (32.10, 51.14)	4.86	<0.001	1.47
Time × Group	−21.73 (−34.55, −8.91)	6.54	0.001	0.57
Sleep quality
Time	0.24 (0.02, 0.45)	0.11	0.03	0.37
Group	0.66 (0.33, 0.99)	0.17	<0.001	0.67
Time × Group	−0.34 (−0.64, −0.03)	0.16	0.03	0.37
Sleep hygiene
Time	0.05 (−0.13, 0.23)	0.09	0.60	0.09
Group	0.20 (−0.11, 0.50)	0.16	0.20	0.22
Time × Group	−0.29 (−0.55, −0.03)	0.13	0.03	0.38
Pain
Time	−14.24 (−24.23, −4.24)	5.10	<0.01	0.48
Group	−33.97 (−48.14, −19.80)	7.23	<0.001	0.81
Time × Group	14.57 (0.33, 28.61)	7.21	0.045	0.34
Anxiety
Time	−3.41 (−4.81, −2.02)	0.71	<0.001	0.82
Group	−4.35 (−6.42, −2.29)	1.05	<0.001	0.71
Time × Group	3.59 (1.62, 5.56)	1.01	<0.001	0.61
Depression
Time	−0.35 (−2.18, 1.48)	0.93	0.71	0.06
Group	−2.00 (−4.84, 0.84)	1.45	0.17	0.24
Time × Group	1.59 (−1.00, 4.18)	1.32	0.23	0.21
HRQOL
Time	13.19 (6.48, 19.91)	3.43	<0.001	0.66
Group	34.75 (24.95, 44.55)	5.00	<0.001	1.19
Time × Group	−18.43 (−27.93, −8.94)	4.84	<0.001	0.65