Table 7.

Predictors of survival.

	Overall Survival			Recurrence-Free Survival
	HR	95% CI	p-Value	HR	95% CI	p-Value
Gender				‡	‡	‡
Preoperative therapy				1.975	1.223–3.191	0.005
Major resection	‡	‡	‡	‡	‡	‡
Extended resection	‡	‡	‡	‡	‡	‡
Visceral extension	‡	‡	‡	‡	‡	‡
Vascular infiltration	‡	‡	‡
Visceral infiltration	‡	‡	‡	‡	‡	‡
Tumor size (<5 vs. 5–10 vs. >10 cm) *	1.674	1.275–2.199	<0.001	1.503	1.166–1.936	0.002
Solitary vs. multifocal tumors				‡	‡	‡
T stage	1.333	1.134–1.566	<0.001	1.250	1.076–1.452	0.004
N stage	1.494	1.149–1.943	0.003	1.276	1.011–1.611	0.040
M stage	‡	‡	‡	2.812	1.507–5.247	0.001
V stage	‡	‡	‡
Pn stage	‡	‡	‡	‡	‡	‡

For survival analyses perioperative deaths (n = 18) were excluded; for multivariate analysis, p-values <0.1 were further analyzed using backward selection (see Table 6); * size of the largest nodule obtained out of the histology report; ‡ eliminated value in backward selection; UICC stage was not included in multivariate analysis due to the fact that multiple tested parameters are included within the UICC staging.