Figure 2.

Correlation between structural defects of specific components of the VCS and conduction abnormalities. (A) Representation of the ventricular conduction system of healthy mice, with a corresponding surface ECG. (B) Representation of morphological abnormalities of one or several components of the ventricular conduction system with the corresponding mouse genotype indicated vertically. Abnormal ECGs are indicated with an increased PR interval associated with hypoplasia of the AVN and/or AVB; a fragmented QRS also referred as RsR’ pattern associated with hypoplasia of bundle branches and a prolonged QRS duration associated with both hypoplasia and hyperplasia of the Purkinje network. AVN: Atrioventricular node, AVB: Atrioventricular bundle, RBB and LBB: right and left bundle branch, PF: Purkinje Fibers, OE: overexpression, ΔLV: mutation of the left ventricle specific enhancer.