Table 2.
QoL changes compared between probiotic versus placebo intervention. IBS: irritable bowel syndrome; QoL: quality of life; ↑↑: QoL improvement in probiotic versus placebo group: ↑↑= p < 0.01, ↑ = p < 0.05; QoL deterioration in probiotic versus placebo group: ↓ = p < 0.05; ↔: no group differences and no trend in QoL; ↔ (+): no significant group differences (trend towards QoL improvement); ↔ (−): no significant differences between groups (trend QoL towards deterioration); NA: not applicable.
| Year | Questionnaire | Result of Subgroups | Total Result | |
|---|---|---|---|---|
| Abbas, Z., et al. | 2014 | IBS - QOL | - | ↑↑ |
| Andresen, V. et al. | 2020 | SF - 12 sum score | - | ↑ |
| Begtrup, L. M., et al. | 2013 | IBS - QOL | - | ↔ (+) |
| Choi, C. H., et al. | 2011 | IBS - QOL | - | ↑ |
| Choi, C. H., et al. | 2015 | IBS - QOL | - | ↔ (+) |
| Cremon, C. et al. | 2018 | SF-12 | - | ↔ |
| Dapoigny, M. et al. | 2012 | GIQLI | - | ↔ |
| Drouault-Holowacz, S., et al. | 2008 | IBS specific FDD-quality-of-life SF-36 | - | ↔ (+) |
| Francavilla, R. et al. | 2019 | IBS QOL | - | ↔ (-) |
| Guglielmetti, S., et al. | 2011 | SF-12 | ↑↑ (mental), ↑ (physical) | NA |
| Gupta, A. K. et al. | 2021 | QoL - Questionnaire | - | NA |
| Guyonnet, D., et al. | 2007 | FDDQL - discomfort | - | ↔ (+) |
| Kajander, K. et al. | 2005 | SF-36 | - | ↔ (NA) |
| Ki Cha, B., et al. | 2012 | IBS-QOL | - | ↔ (+) |
| Kruis, W. et al. | 2012 | HRQL | - | ↔ (+) |
| Lewis, E. et al. | 2020 | SF - 36 IBS - QOL | - | ↔ (+) |
| Lorenzo-Zúñiga, V., et al. | 2014 | IBS - QOL | - | ↑ |
| Lyra, A., et al. | 2016 | IBS-QOL | - | ↔ (+) |
| Majeed, M., et al. | 2016 | IBS-QOL | - | ↑↑ |
| Majeed, M., et al. | 2018 | IBS-QOL | - | ↓ |
| Martoni, C. J., et al. | 2020 | IBS-QOL | - | ↓ |
| Niv, E., et al. | 2005 | IBS-QOL | - | ↔ (-) |
| O’Mahony, L., et al. | 2005 | IBS-QOL | ↓ in "health worry" for B. infantis | NA |
| Pinto-Sanchez, M. I., et al. | 2017 | SF-36 | ↑ in physical subdomain | NA |
| Preston, K., et al. | 2018 | IBS-QOL-Questionnaire | - | NA |
| Ringel-Kulka, T., et al. | 2011 | IBS-QOL | - | ↔ (+) |
| Simrén, M., et al. | 2010 | IBS-QOL | - | ↔ (+) |
| Sisson, G., et al. | 2014 | IBS-QOL | - | ↔ (+) |
| Staudacher, H. et al. | 2017 | IBS-QOL SF-36 | - | ↔ (+) |
| Stevenson, C., et al. | 2014 | IBS-QOL | - | ↔ (-) |
| Sun, Y. Y., et al. | 2018 | IBS-QOL | - | ↑ |
| Thijssen, A. Y., et al. | 2016 | QOL Physical composite scoreQOL mental composite score | - | ↔ |
| Whorwell, P. J., et al. | 2006 | IBS-QOL | - | ↔ (NA) |
| Williams, E. A., et al. | 2009 | IBS-SSS-QOL | - | ↑↑ |
| Wong, R. K., et al. | 2015 | IBS-SSS-QOL | - | ↔ |