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Association between GDF-15 concentration and in-hospital mortality hazard ratio by restricted cubic spline regression model. The reference value is the median of the first tertile (5187.3 pg/mL). The red line indicates the estimated hazard ratio; the dashed green line indicates the reference line of null hypothesis that the hazard ratio is 1; the dashed black lines indicate the lower and upper 95% confidence limits. Abbreviation: GDF-15, growth differentiation factor-15.
