. 2021 Aug 18;10(16):3644. doi: 10.3390/jcm10163644

Table 2.

Comparison of the level of immunoglobulins (mg/dL) in serum samples of test and placebo group at day 0, 30 and 60 using flow cytometry.

	Test Group			Within Group Analysis of Test Group						Placebo Group		P➔T **	Within Group Analysis				Between Group Analysis
	Test Group			Within Group Analysis of Test Group						Placebo Group		Crossover Group	Placebo Group		P➔T ** Crossover Group		Between Group Analysis
	Day 0	Day 30	Day 60	Day 0–30		Day 30–60		Day 0–60		Day 0	Day 30	Day 60	Day 0–30		Day 30–60		Day 0	Day 30
	Mean ± SE	Mean ± SE	Mean ± SE	% Change	p Value ^#	% Change	p Value ^#	% Change	p Value ^#	Mean ± SE	Mean ± SE	Mean ± SE	% Change	p Value ^#	% Change	p Value ^#	p Value ^$	p Value ^$
IgA	170.06 ± 16.99	180.2 ± 18.28	184.13 ± 18.66	5.96	<0.001	2.18	<0.001	8.27	<0.001	169.9 ± 14.95	174.88 ± 15.76	183.62 ± 16.55	2.93	0.764	5	<0.001	0.994	0.828
IgG2	212.16 ± 16.4	217.5 ± 16.71	224.69 ± 17.25	2.52	<0.001	3.31	<0.001	5.91	<0.001	205.97 ± 21.36	183.74 ± 15.4	189.25 ± 15.86	−10.79	0.286	3	<0.001	0.82	0.151
IgG3	47.63 ± 3.72	48.83 ± 3.81	50.87 ± 3.97	2.52	<0.001	4.18	<0.001	6.8	<0.001	43.03 ± 3.5	50.36 ± 5.38	50.76 ± 5.42	17.03	0.172	0.79	<0.001	0.377	0.819
IgG4	24.96 ± 2.64	25.97 ± 2.76	27.37 ± 2.90	4.05	<0.001	5.39	<0.001	9.66	<0.001	24.95 ± 2.67	26.42 ± 2.47	26.95 ± 2.52	5.89	0.704	2.01	<0.001	0.997	0.906
IgG	801.44 ± 59.19	842.23 ± 62.2	894.14 ± 66.12	5.09	<0.001	6.16	<0.001	11.57	<0.001	822.99 ± 69.52	836.58 ± 70.88	881.75 ± 74.71	1.65	0.879	5.4	<0.001	0.816	0.953
IgM	183.9 ± 34.41	185.43 ± 34.67	200.7 ± 37.54	0.83	<0.001	8.23	<0.001	9.14	<0.001	184.14 ± 55.64	185.17 ± 55.97	186.41 ± 56.34	0.56	0.99	0.67	0.002 *	0.997	0.299 *

^# Within group significance using the t-test (equal variances). ^$ Between the group significance using the t-test for independent groups. * p value using Mann–Whitney test. P➔T ** Placebo group crossed over to the test group in the extension study period.