. 2021 Aug 18;10(16):3644. doi: 10.3390/jcm10163644

Table 3.

Comparison of the level of T cells, B cells, NK cells count (cells/µL) in whole blood and cytokines IL4 and IFNγ level (pg/mL) in serum samples of test and placebo group at day 0, 30 and 60 using flow cytometry.

	Test Group			Within Group Analysis of Test Group						Placebo Group		P➔T ** Crossover Group	Within Group Analysis				Between Group Analysis
	Test Group			Within Group Analysis of Test Group						Placebo Group		P➔T ** Crossover Group	Placebo Group		P➔T ** Crossover Group		Between Group Analysis
	Day 0	Day 30	Day 60	Day 0–30		Day 30–60		Day 0–60		Day 0	Day 30	Day 60	Day 0–30		Day 30–60		Day 0	Day 30
	Mean ± SE	Mean ± SE	Mean ± SE	% Change	p Value ^#	% Change	p Value ^#	% Change	p Value ^#	Mean ± SE	Mean ± SE	Mean ± SE	% Change	p Value ^#	% Change	p Value ^#	p Value ^$	p Value ^$
CD45	2148.03 ± 159.54	2492.41 ± 105.24	2854.3 ± 92.85	12.07	0.032	14.52	<0.001	32.88	0.001	2201.22 ± 191.39	1852.96 ± 122.25	2255.87 ± 132.64	−15.44	0.009	21.74	0.036	0.833	0.001
CD3	1334.71 ± 98.24	1699.4 ± 76.06	1874.02 ± 90.06	19.46	0.001	10.28	0.026	40.41	0.002	1595.16 ± 109.60	1253.94 ± 68.87	1550.93 ± 96.93	−22.00	0.002	23.68	0.01	0.091	<0.001
CD4	738.23 ± 54.71	918.25 ± 49.85	1042.82 ± 49.84	17.26	0.003	13.57	0.018	41.26	0.001	876.88 ± 59.59	669.3 ± 47.57	860.34 ± 54.87	−24.13	0.001	28.54	0.005	0.101	0.002
CD8	498.95 ± 39.11	603.31 ± 24.77	716.47 ± 52.85	14.57	0.005	18.76	0.028	43.6	0.003	604.37 ± 53.12	455.06 ± 24.24	594.18 ± 43.47	−25.13	0.02	30.57	0.01	0.124	<0.001
CD19	661.53 ± 29.81	761.98 ± 30.87	974.39 ± 63.75	10.31	0.034	27.88	0.021	47.29	0.004	751.06 ± 32.04	734.83 ± 28.08	870.1 ± 42.12	−1.87	0.733	18.41	0.006	0.053	0.522
NK	361.92 ± 66.06	467.36 ± 68.41	552.68 ± 62.51	19.08	0.046	18.26	0.015	52.71	<0.001	341.95 ± 60.83	341.26 ± 42.73	465.47 ± 35.37	−0.15	0.989	36.4	0.027	0.826	0.132
IFNγ	72.15 ± 7.25	100.60 ± 10.67	111.61 ± 7.64	39.44	<0.001	10.94	0.056	54.69	<0.001	73.36 ± 6.11	72.06 ± 5.70	97.65 ± 9.01	−1.77	0.749	35.51	<0.001	0.899	0.028
IL4	3.92 ± 1.42	7.16 ± 1.51	9.30 ± 1.13	82.53	0.047	29.89	0.053	137.06	0.004	4.20 ± 1.94	3.21 ± 1.35	6.29 ± 0.80	−23.50	0.814 *	95.87	0.038 *	0.817	0.03

^# Within group significance using the t-test (equal variances). ^$ Between the group significance using the t-test for independent groups. * p value using Mann–Whitney test. P➔T ** Placebo group crossed over to the test group in the extension study period.