Table 1.
Characteristics of the included articles.
| Author (Publication Year) | Study Design | Study Location | Cohort of Surveillance | No. of Patients (% Cirrhosis) |
Age, Years * | Most Common Etiology | No. of Patients with HCC | US Machine | Sonographer Experience | Test for Surveillance | Interval of Test | Reference Standard | Follow-Up Period, Months * |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kim YY (2019) | Retrospective | South Korea | Patients with hepatic observation | 155 (N.A.) | 59.4 ± 8.9 * |
Hepatitis B | 155 | NA | 1–4 years | US plus AFP | 6 months | Pathology, CT or MRI |
NA |
| Millet JD (2019) | Retrospective | U.S. | Total cohort ** | 2050 (51.4) | 57.7, mean | Hepatitis B | 29 | Multiple | 19.3 ± 12.3 * | US plus AFP | 6 months | Pathology, CT or MRI |
21.7 ± 2.7 * |
| Pinero F (2019) | Retrospective | Argentina | Patients with hepatic observation | 345 (100) |
62 ± 8.8 * 61 ± 9.6 * |
Hepatitis C | 345 | NA | NA | US plus AFP | 6 months | Pathology, CT or MRI |
NA |
| Son JH (2019) | Retrospective | South Korea | Total cohort ** | 407 (100) |
56, median (28–76) |
Hepatitis B | 28 | Single | >14 years | US alone | 6 months | Pathology, CT or MRI |
18, median |
| Samoylova ML (2018) | Retrospective | U.S. | Patients with hepatic observation | 352 (NA) | 60, median (56–65) |
Hepatitis C | 352 | NA | NA | US plus AFP | NA | CT or MRI |
NA |
| Simmons O (2017) | Retrospective | U.S. | Total cohort ** | 941 (100) |
56.5 ± 9.9 * |
Hepatitis C | NA | Multiple | NA | US plus AFP | 6 months | NA | NA |
Articles are listed according to the year of publication and alphabetical order of the names of the first authors within the same year of publication. * Data are presented as the means ± standard deviations. ** Total cohort includes patients without hepatic observations as well as those with hepatic observations. HCC, hepatocellular carcinoma; No, number; US, ultrasound; AFP, alpha-fetoprotein; CT, computed tomography; MRI, magnetic resonance imaging; NA, not available.