. Author manuscript; available in PMC: 2022 Sep 1.

Published in final edited form as: J Acquir Immune Defic Syndr. 2021 Sep 1;88(1):19–30. doi: 10.1097/QAI.0000000000002743

Table 1:

Modelled HIV/HSV-2 cofactors.

Cofactor	Description	Prior distribution used in model			Source (see appendix)
Cofactor	Description	Conservative scenario^a	Liberal scenario^a	Fully liberal scenario^a	Source (see appendix)
1	Per-act increased risk of HIV acquisition for HSV-2-infected individuals a) For recent HSV-2 infection ${R R}_{r a}^{H I V - A, s = 2}$ b) For established HSV-2 infection ${R R}_{r a}^{H I V - A, s = 3}$	All females: T (7.2, 1, 12)^b All males: T (4.7, 1, 11) Lower-risk females: T (2.5, 1, 4) Lower-risk males: T (3.1, 1, 5) FSWs^c: T (1.5, 1, 3) CFSWs^d: T (1.8, 1, 3)			Adapted from ³, See Table S4 and section 2.2 of appendix
2	Per-act increased risk of HIV transmission for HSV-2-infected individuals ( $R R^{H I V - T, \tilde{s}}$ )	1	T (1.33,1,1.93)		See Table C1 and section C1.3
3	Per-act increased risk of HSV-2 transmission for HIV-infected individuals ( $R R^{H S V - T, \tilde{i}}$ )	1	1	T (2.55,1.39,4.68)	See Table C1 and section C1.4
4	Efficacy of ART in reducing the per-act increase in HSV-2 transmission risk due to HIV per sex act ( ${R R}_{A R T - T}^{H S V, \tilde{i}}$ )	1	1	T (0.58,0.37,0.92)	See Table C1 and section C1.5
5	Effect of HSV-2 on the efficacy of ART in reducing per-act HIV transmission risk ( ${R R}_{H S V / A R T - T}^{H I V}$ )	1	1	U (0.95-1.00)^e	See Table C1 and section C1.6

Description of per-act HIV/HSV-2 cofactor prior distributions used in the model under the different model scenarios.

Conservative scenario: HSV-2 only increases HIV acquisition risk; liberal scenario: HSV-2 increases HIV acquisition and transmission risk; fully liberal scenario: HSV-2 increases HIV acquisition and transmission risk, HIV increases HSV-2 transmission risk but this is reduced if the individual is on ART, and HSV-2 can slightly alter the effect of ART on HIV transmission risk.

T(m,a,b) – triangular distribution (m=mode, a=minimum, b=maximum).

CFSWs – clients of FSWs

FSW – female sex workers.

U(a,b) – uniform distribution (a=minimum, b=maximum).