Table 1. Hypoxia-induced and HIF-dependent genes involved in axon guidance (GO: 7411), axonogenesis (GO: 7409), and postsynaptic density assembly (GO: 0097107).

Gene name	FC*	PADI†	TCGA‡
ARTN	4.01	Yes	Yes
BRSK2	1.78	Yes	Yes
DOCK7	1.56	Yes	Yes
DOK4	1.77	Yes	Yes
DOK5	2.3	Yes	Yes
EFNA1	2.1	Yes	Yes
EFNA2	4.08	No	Yes
EFNA3	4.99	Yes	Yes
EFNB3	3.71	Yes	No
EVL	1.75	Yes	No
GRB10	3.92	Yes	Yes
L1CAM	9.47	Yes	Yes
LINGO3	83.7	Yes	No
MAPK3	1.82	Yes	No
MAPK7	2.34	Yes	Yes
MAPK11	1.54	Yes	Yes
NAV1	1.77	Yes	No
NCAM1	1.74	Yes	Yes
NLGN2	1.79	Yes	Yes
NRXN2	2.62	Yes	No
NTN1	1.57	Yes	No
NTN3	10.2	Yes	No
NTNG2	2.06	No	Yes
PAK3	2.48	Yes	Yes
PLXNA3	3.11	Yes	No
PLXNB3	9.23	Yes	Yes
RAB3A	1.9	Yes	No
RAP1GAP	2.21	Yes	No
RNF165	3.59	Yes	No
SEMA3F	1.82	Yes	No
SHANK1	3.02	Yes	No
SHANK3	1.61	Yes	No
SHC3	1.69	Yes	Yes
SPTBN5	2.53	Yes	No
TNFRSF8	3.17	Yes	Yes
VEGFA	3.46	Yes	Yes
VLDLR	10.1	Yes	Yes

*Fold change in expression in SUM159 cells exposed to 1% O₂ compared to 20% O₂.

†Hypoxic induction is also PADI4 dependent.

‡Gene expression is significantly correlated with expression of HIF signature in TCGA breast cancer database (P < 0.01, Pearson’s test).